Study Session · Yoel QBank

Review — marked for review — Question 2 of 8

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A 61-year-old woman comes to the office due to a neck lump. There is a nontender, firm nodule in the left lobe of the thyroid. Serum TSH is normal. Ultrasonography reveals a 2-cm hypoechoic nodule with increased central blood flow. Fine-needle aspiration biopsy shows clusters of cells with large, overlapping nuclei containing sparse, finely dispersed chromatin, plus numerous intranuclear inclusion bodies and grooves. Which of the following is the most likely diagnosis?

Incorrect — the correct answer is F

Explanation

Respuesta correcta: F. Papillary carcinoma. Clave clínica (stem-killer): Nódulo + Orphan Annie eye nuclei + PSAMMOMA bodies + nuclear grooves → carcinoma PAPILAR (el más común). Disemina por linfáticos; buen pronóstico.

Educational objective

Papillary thyroid cancer is the most common thyroid cancer. Histology shows large cells with nuclei containing finely dispersed chromatin giving an empty/ground-glass appearance (Orphan Annie eye) plus intranuclear inclusions or grooves.

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Details

Source: UWorld
Personal notes: Tema: Carcinoma papilar de tiroides

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